Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. [electronic resource]
Producer: 20190624Description: 1913-1928 p. digitalISSN:- 1540-9538
- Animals
- Apoptosis -- drug effects
- Cell Line, Tumor
- Down-Regulation
- Drug Resistance, Neoplasm
- F-Box-WD Repeat-Containing Protein 7 -- metabolism
- Gene Deletion
- Glycine -- analogs & derivatives
- HEK293 Cells
- Humans
- MAP Kinase Signaling System
- Melanoma -- drug therapy
- Mice
- Prognosis
- Protein Stability
- Proteolysis
- Proto-Oncogene Proteins B-raf -- metabolism
- Sulfones -- pharmacology
- Ubiquitin Thiolesterase -- deficiency
- Vemurafenib -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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