Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells. [electronic resource]
Producer: 20170420Description: 139-47 p. digitalISSN:- 1872-7573
- Animals
- Antineoplastic Agents, Phytogenic -- isolation & purification
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Biomarkers, Tumor -- metabolism
- Breast Neoplasms -- drug therapy
- Carcinoma, Ehrlich Tumor -- drug therapy
- Cell Cycle Checkpoints -- drug effects
- Cell Cycle Proteins -- metabolism
- DNA Damage
- Dose-Response Relationship, Drug
- Ethanol -- chemistry
- Female
- HT29 Cells
- Humans
- Lipid Peroxidation -- drug effects
- MCF-7 Cells
- Male
- Mice, Inbred BALB C
- Oxidants -- isolation & purification
- Oxidative Stress -- drug effects
- Phytotherapy
- Piper nigrum -- chemistry
- Piperidines -- isolation & purification
- Plant Extracts -- isolation & purification
- Plants, Medicinal
- Protein Carbonylation -- drug effects
- Reactive Oxygen Species -- metabolism
- Solvents -- chemistry
- Time Factors
- Tumor Burden -- drug effects
- Up-Regulation
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Publication Type: Journal Article
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