Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells.

de Souza Grinevicius, Valdelúcia Maria Alves

Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells. [electronic resource] - Journal of ethnopharmacology Aug 2016 - 139-47 p. digital

Publication Type: Journal Article

1872-7573

10.1016/j.jep.2016.05.020 doi


Animals
Antineoplastic Agents, Phytogenic--isolation & purification
Apoptosis--drug effects
Apoptosis Regulatory Proteins--metabolism
Biomarkers, Tumor--metabolism
Breast Neoplasms--drug therapy
Carcinoma, Ehrlich Tumor--drug therapy
Cell Cycle Checkpoints--drug effects
Cell Cycle Proteins--metabolism
DNA Damage
Dose-Response Relationship, Drug
Ethanol--chemistry
Female
HT29 Cells
Humans
Lipid Peroxidation--drug effects
MCF-7 Cells
Male
Mice, Inbred BALB C
Oxidants--isolation & purification
Oxidative Stress--drug effects
Phytotherapy
Piper nigrum--chemistry
Piperidines--isolation & purification
Plant Extracts--isolation & purification
Plants, Medicinal
Protein Carbonylation--drug effects
Reactive Oxygen Species--metabolism
Solvents--chemistry
Time Factors
Tumor Burden--drug effects
Up-Regulation