Results
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81.
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Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). [electronic resource] by
- Gogliotti, Rocco D
- Blobaum, Anna L
- Morrison, Ryan M
- Daniels, J Scott
- Salovich, James M
- Cheung, Yiu-Yin
- Rodriguez, Alice L
- Loch, Matthew T
- Conn, P Jeffrey
- Lindsley, Craig W
- Niswender, Colleen M
- Hopkins, Corey R
Producer: 20170710
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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82.
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N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents. [electronic resource] by
- Felts, Andrew S
- Rodriguez, Alice L
- Morrison, Ryan D
- Venable, Daryl F
- Blobaum, Anna L
- Byers, Frank W
- Daniels, J Scott
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20161213
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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83.
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Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. [electronic resource] by
- Amato, Russell J
- Felts, Andrew S
- Rodriguez, Alice L
- Venable, Daryl F
- Morrison, Ryan D
- Byers, Frank W
- Daniels, J Scott
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
- Jones, Carrie K
- Emmitte, Kyle A
Producer: 20140401
In:
ACS chemical neuroscience vol. 4
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84.
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Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles. [electronic resource] by
- Rook, Jerri M
- Tantawy, Mohammed N
- Ansari, Mohammad S
- Felts, Andrew S
- Stauffer, Shaun R
- Emmitte, Kyle A
- Kessler, Robert M
- Niswender, Colleen M
- Daniels, J Scott
- Jones, Carrie K
- Lindsley, Craig W
- Conn, P Jeffrey
Producer: 20160315
In:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 40
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85.
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Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. [electronic resource] by
- Bender, Aaron M
- Weiner, Rebecca L
- Luscombe, Vincent B
- Ajmera, Sonia
- Cho, Hyekyung P
- Chang, Sichen
- Zhan, Xiaoyan
- Rodriguez, Alice L
- Niswender, Colleen M
- Engers, Darren W
- Bridges, Thomas M
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20170818
In:
Bioorganic & medicinal chemistry letters vol. 27
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86.
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Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. [electronic resource] by
- Lewis, L Michelle
- Sheffler, Douglas
- Williams, Richard
- Bridges, Thomas M
- Kennedy, J Phillip
- Brogan, J T
- Mulder, Matthew J
- Williams, Lyndsey
- Nalywajko, Natalia T
- Niswender, Colleen M
- Weaver, Charles D
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20080324
In:
Bioorganic & medicinal chemistry letters vol. 18
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87.
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Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. [electronic resource] by
- Panarese, Joseph D
- Cho, Hykeyung P
- Adams, Jeffrey J
- Nance, Kellie D
- Garcia-Barrantes, Pedro M
- Chang, Sichen
- Morrison, Ryan D
- Blobaum, Anna L
- Niswender, Colleen M
- Stauffer, Shaun R
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20170620
In:
Bioorganic & medicinal chemistry letters vol. 26
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88.
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Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. [electronic resource] by
- Felts, Andrew S
- Bollinger, Katrina A
- Brassard, Christopher J
- Rodriguez, Alice L
- Morrison, Ryan D
- Scott Daniels, J
- Blobaum, Anna L
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Emmitte, Kyle A
- Lindsley, Craig W
Producer: 20191104
In:
Bioorganic & medicinal chemistry letters vol. 29
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89.
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N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. [electronic resource] by
- Lovell, Kimberly M
- Felts, Andrew S
- Rodriguez, Alice L
- Venable, Daryl F
- Cho, Hyekyung P
- Morrison, Ryan D
- Byers, Frank W
- Daniels, J Scott
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20140113
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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90.
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Discovery of ML326: The first sub-micromolar, selective M5 PAM. [electronic resource] by
- Gentry, Patrick R
- Bridges, Thomas M
- Lamsal, Atin
- Vinson, Paige N
- Smith, Emery
- Chase, Peter
- Hodder, Peter S
- Engers, Julie L
- Niswender, Colleen M
- Daniels, J Scott
- Conn, P Jeffrey
- Wood, Michael R
- Lindsley, Craig W
Producer: 20131126
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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91.
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Novel M [electronic resource] by
- Poslusney, Michael S
- Salovich, James M
- Wood, Michael R
- Melancon, Bruce J
- Bollinger, Katrina A
- Luscombe, Vincent B
- Rodriguez, Alice L
- Engers, Darren W
- Bridges, Thomas M
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20191209
In:
Bioorganic & medicinal chemistry letters vol. 29
Availability: No items available.
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92.
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Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4). [electronic resource] by
- Smith, Emery
- Chase, Peter
- Niswender, Colleen M
- Utley, Thomas J
- Sheffler, Douglas J
- Noetzel, Meredith J
- Lamsal, Atin
- Wood, Michael R
- Conn, P Jeffrey
- Lindsley, Craig W
- Madoux, Franck
- Acosta, Mary
- Scampavia, Louis
- Spicer, Timothy
- Hodder, Peter
Producer: 20160505
In:
Journal of biomolecular screening vol. 20
Availability: No items available.
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93.
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Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M [electronic resource] by
- Long, Madeline F
- Engers, Julie L
- Chang, Sichen
- Zhan, Xiaoyan
- Weiner, Rebecca L
- Luscombe, Vincent B
- Rodriguez, Alice L
- Cho, Hyekyung P
- Niswender, Colleen M
- Bridges, Thomas M
- Conn, P Jeffrey
- Engers, Darren W
- Lindsley, Craig W
Producer: 20171121
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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94.
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Discovery of a novel, CNS penetrant M [electronic resource] by
- Bewley, Blake R
- Spearing, Paul K
- Weiner, Rebecca L
- Luscombe, Vincent B
- Zhan, Xiaoyan
- Chang, Sichen
- Cho, Hyekyung P
- Rodriguez, Alice L
- Niswender, Colleen M
- Conn, P Jeffrey
- Bridges, Thomas M
- Engers, Darren W
- Lindsley, Craig W
Producer: 20170915
In:
Bioorganic & medicinal chemistry letters vol. 27
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95.
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Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism. [electronic resource] by
- Sheffler, Douglas J
- Sevel, Christian
- Le, Uyen
- Lovell, Kimberly M
- Tarr, James C
- Carrington, Sheridan J S
- Cho, Hyekyung P
- Digby, Gregory J
- Niswender, Colleen M
- Conn, P Jeffrey
- Hopkins, Corey R
- Wood, Michael R
- Lindsley, Craig W
Producer: 20130528
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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96.
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Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). [electronic resource] by
- Gentry, Patrick R
- Kokubo, Masaya
- Bridges, Thomas M
- Noetzel, Meredith J
- Cho, Hyekyung P
- Lamsal, Atin
- Smith, Emery
- Chase, Peter
- Hodder, Peter S
- Niswender, Colleen M
- Daniels, J Scott
- Conn, P Jeffrey
- Lindsley, Craig W
- Wood, Michael R
Producer: 20141203
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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97.
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Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M [electronic resource] by
- Temple, Kayla J
- Engers, Julie L
- Long, Madeline F
- Watson, Katherine J
- Chang, Sichen
- Luscombe, Vincent B
- Jenkins, Matthew T
- Rodriguez, Alice L
- Niswender, Colleen M
- Bridges, Thomas M
- Conn, P Jeffrey
- Engers, Darren W
- Lindsley, Craig W
Producer: 20210128
In:
Bioorganic & medicinal chemistry letters vol. 30
Availability: No items available.
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98.
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Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012. [electronic resource] by
- Melancon, Bruce J
- Utley, Thomas J
- Sevel, Christian
- Mattmann, Margrith E
- Cheung, Yiu-Yin
- Bridges, Thomas M
- Morrison, Ryan D
- Sheffler, Douglas J
- Niswender, Colleen M
- Daniels, J Scott
- Conn, P Jeffrey
- Lindsley, Craig W
- Wood, Michael R
Producer: 20121130
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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99.
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Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. [electronic resource] by
- Engers, Darren W
- Field, Julie R
- Le, Uyen
- Zhou, Ya
- Bolinger, Julie D
- Zamorano, Rocio
- Blobaum, Anna L
- Jones, Carrie K
- Jadhav, Satyawan
- Weaver, C David
- Conn, P Jeffrey
- Lindsley, Craig W
- Niswender, Colleen M
- Hopkins, Corey R
Producer: 20110419
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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100.
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Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M [electronic resource] by
- Moehle, Mark S
- Pancani, Tristano
- Byun, Nellie
- Yohn, Samantha E
- Wilson, George H
- Dickerson, Johnathan W
- Remke, Daniel H
- Xiang, Zixiu
- Niswender, Colleen M
- Wess, Jürgen
- Jones, Carrie K
- Lindsley, Craig W
- Rook, Jerri M
- Conn, P Jeffrey
Producer: 20190705
In:
Neuron vol. 96
Availability: No items available.
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