Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. [electronic resource]
Producer: 20170620Description: 3822-5 p. digitalISSN:- 1464-3405
- Allosteric Regulation -- drug effects
- Animals
- Central Nervous System -- drug effects
- Central Nervous System Agents -- chemical synthesis
- Dose-Response Relationship, Drug
- Drug Discovery
- Heterocyclic Compounds -- chemical synthesis
- Molecular Structure
- Pyridines -- chemical synthesis
- Pyrroles -- chemical synthesis
- Rats
- Receptor, Muscarinic M1 -- metabolism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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