Results
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61.
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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. [electronic resource] by
- Noetzel, Meredith J
- Rook, Jerri M
- Vinson, Paige N
- Cho, Hyekyung P
- Days, Emily
- Zhou, Y
- Rodriguez, Alice L
- Lavreysen, Hilde
- Stauffer, Shaun R
- Niswender, Colleen M
- Xiang, Zixiu
- Daniels, J Scott
- Jones, Carrie K
- Lindsley, Craig W
- Weaver, C David
- Conn, P Jeffrey
Producer: 20120504
In:
Molecular pharmacology vol. 81
Availability: No items available.
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62.
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Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. [electronic resource] by
- Felts, Andrew S
- Rodriguez, Alice L
- Smith, Katrina A
- Engers, Julie L
- Morrison, Ryan D
- Byers, Frank W
- Blobaum, Anna L
- Locuson, Charles W
- Chang, Sichen
- Venable, Daryl F
- Niswender, Colleen M
- Daniels, J Scott
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20160314
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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63.
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Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold. [electronic resource] by
- Rodriguez, Alice L
- Zhou, Ya
- Williams, Richard
- Weaver, C David
- Vinson, Paige N
- Dawson, Eric S
- Steckler, Thomas
- Lavreysen, Hilde
- Mackie, Claire
- Bartolomé, José M
- Macdonald, Gregor J
- Daniels, J Scott
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Stauffer, Shaun R
Producer: 20130520
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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64.
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Discovery of VU6005649, a CNS Penetrant mGlu [electronic resource] by
- Abe, Masahito
- Seto, Mabel
- Gogliotti, Rocco G
- Loch, Matthew T
- Bollinger, Katrina A
- Chang, Sichen
- Engelberg, Eileen M
- Luscombe, Vincent B
- Harp, Joel M
- Bubser, Michael
- Engers, Darren W
- Jones, Carrie K
- Rodriguez, Alice L
- Blobaum, Anna L
- Conn, P Jeffrey
- Niswender, Colleen M
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Oct 2017
In:
ACS medicinal chemistry letters vol. 8
Availability: No items available.
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65.
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Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu [electronic resource] by
- Engers, Darren W
- Bollinger, Sean R
- Engers, Julie L
- Panarese, Joseph D
- Breiner, Megan M
- Gregro, Alison
- Blobaum, Anna L
- Bronson, Joanne J
- Wu, Yong-Jin
- Macor, John E
- Rodriguez, Alice L
- Zamorano, Rocio
- Conn, P Jeffrey
- Lindsley, Craig W
- Niswender, Colleen M
- Hopkins, Corey R
Producer: 20190206
In:
Bioorganic & medicinal chemistry letters vol. 28
Availability: No items available.
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66.
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Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. [electronic resource] by
- Engers, Julie L
- Rodriguez, Alice L
- Konkol, Leah C
- Morrison, Ryan D
- Thompson, Analisa D
- Byers, Frank W
- Blobaum, Anna L
- Chang, Sichen
- Venable, Daryl F
- Loch, Matthew T
- Niswender, Colleen M
- Daniels, J Scott
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20151229
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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67.
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VU6010608, a Novel mGlu [electronic resource] by
- Reed, Carson W
- McGowan, Kevin M
- Spearing, Paul K
- Stansley, Branden J
- Roenfanz, Hanna F
- Engers, Darren W
- Rodriguez, Alice L
- Engelberg, Eileen M
- Luscombe, Vincent B
- Loch, Matthew T
- Remke, Daniel H
- Rook, Jerri M
- Blobaum, Anna L
- Conn, P Jeffrey
- Niswender, Colleen M
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Dec 2017
In:
ACS medicinal chemistry letters vol. 8
Availability: No items available.
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68.
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Design and Synthesis of [electronic resource] by
- Engers, Julie L
- Bollinger, Katrina A
- Weiner, Rebecca L
- Rodriguez, Alice L
- Long, Madeline F
- Breiner, Megan M
- Chang, Sichen
- Bollinger, Sean R
- Bubser, Michael
- Jones, Carrie K
- Morrison, Ryan D
- Bridges, Thomas M
- Blobaum, Anna L
- Niswender, Colleen M
- Conn, P Jeffrey
- Emmitte, Kyle A
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Sep 2017
In:
ACS medicinal chemistry letters vol. 8
Availability: No items available.
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69.
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Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. [electronic resource] by
- Le, Uyen
- Melancon, Bruce J
- Bridges, Thomas M
- Vinson, Paige N
- Utley, Thomas J
- Lamsal, Atin
- Rodriguez, Alice L
- Venable, Daryl
- Sheffler, Douglas J
- Jones, Carrie K
- Blobaum, Anna L
- Wood, Michael R
- Daniels, J Scott
- Conn, P Jeffrey
- Niswender, Colleen M
- Lindsley, Craig W
- Hopkins, Corey R
Producer: 20130528
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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70.
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Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. [electronic resource] by
- Marlo, Joy E
- Niswender, Colleen M
- Days, Emily L
- Bridges, Thomas M
- Xiang, Yun
- Rodriguez, Alice L
- Shirey, Jana K
- Brady, Ashley E
- Nalywajko, Tasha
- Luo, Qingwei
- Austin, Cheryl A
- Williams, Michael Baxter
- Kim, Kwangho
- Williams, Richard
- Orton, Darren
- Brown, H Alex
- Lindsley, Craig W
- Weaver, C David
- Conn, P Jeffrey
Producer: 20090316
In:
Molecular pharmacology vol. 75
Availability: No items available.
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71.
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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. [electronic resource] by
- Niswender, Colleen M
- Johnson, Kari A
- Weaver, C David
- Jones, Carrie K
- Xiang, Zixiu
- Luo, Qingwei
- Rodriguez, Alice L
- Marlo, Joy E
- de Paulis, Tomas
- Thompson, Analisa D
- Days, Emily L
- Nalywajko, Tasha
- Austin, Cheryl A
- Williams, Michael Baxter
- Ayala, Jennifer E
- Williams, Richard
- Lindsley, Craig W
- Conn, P Jeffrey
Producer: 20081117
In:
Molecular pharmacology vol. 74
Availability: No items available.
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72.
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Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. [electronic resource] by
- Wood, Michael R
- Noetzel, Meredith J
- Tarr, James C
- Rodriguez, Alice L
- Lamsal, Atin
- Chang, Sichen
- Foster, Jarrett J
- Smith, Emery
- Chase, Peter
- Hodder, Peter S
- Engers, Darren W
- Niswender, Colleen M
- Brandon, Nicholas J
- Wood, Michael W
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20170829
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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73.
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Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Bertron, Jeanette L
- Weiner, Rebecca L
- Rodriguez, Alice L
- Lamsal, Atin
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20170818
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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74.
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Corrigendum to "Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Melancon, Bruce J
- Lamsal, Atin
- Luscombe, Vincent B
- Rodriguez, Alice L
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Engers, Darren W
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Jeffrey Conn, P
- Bridges, Thomas M
- Lindsley, Craig W
Publication details: Bioorganic & medicinal chemistry letters 09 2018
In:
Bioorganic & medicinal chemistry letters vol. 28
Availability: No items available.
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75.
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Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. [electronic resource] by
- Mueller, Ralf
- Dawson, Eric S
- Meiler, Jens
- Rodriguez, Alice L
- Chauder, Brian A
- Bates, Brittney S
- Felts, Andrew S
- Lamb, Jeffrey P
- Menon, Usha N
- Jadhav, Sataywan B
- Kane, Alexander S
- Jones, Carrie K
- Gregory, Karen J
- Niswender, Colleen M
- Conn, P Jeffrey
- Olsen, Christopher M
- Winder, Danny G
- Emmitte, Kyle A
- Lindsley, Craig W
Producer: 20120713
In:
ChemMedChem vol. 7
Availability: No items available.
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76.
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Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Melancon, Bruce J
- Lamsal, Atin
- Luscombe, Vincent B
- Rodriguez, Alice L
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Engers, Darren W
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20171218
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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77.
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. [electronic resource] by
- Rodriguez, Alice L
- Grier, Mark D
- Jones, Carrie K
- Herman, Elizabeth J
- Kane, Alexander S
- Smith, Randy L
- Williams, Richard
- Zhou, Ya
- Marlo, Joy E
- Days, Emily L
- Blatt, Tasha N
- Jadhav, Satyawan
- Menon, Usha N
- Vinson, Paige N
- Rook, Jerri M
- Stauffer, Shaun R
- Niswender, Colleen M
- Lindsley, Craig W
- Weaver, C David
- Conn, P Jeffrey
Producer: 20101217
In:
Molecular pharmacology vol. 78
Availability: No items available.
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78.
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Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. [electronic resource] by
- Felts, Andrew S
- Rodriguez, Alice L
- Blobaum, Anna L
- Morrison, Ryan D
- Bates, Brittney S
- Thompson Gray, Analisa
- Rook, Jerri M
- Tantawy, Mohammed N
- Byers, Frank W
- Chang, Sichen
- Venable, Daryl F
- Luscombe, Vincent B
- Tamagnan, Gilles D
- Niswender, Colleen M
- Daniels, J Scott
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20170811
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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79.
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Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects. [electronic resource] by
- Gould, Robert W
- Amato, Russell J
- Bubser, Michael
- Joffe, Max E
- Nedelcovych, Michael T
- Thompson, Analisa D
- Nickols, Hilary H
- Yuh, Johannes P
- Zhan, Xiaoyan
- Felts, Andrew S
- Rodriguez, Alice L
- Morrison, Ryan D
- Byers, Frank W
- Rook, Jerri M
- Daniels, John S
- Niswender, Colleen M
- Conn, P Jeffrey
- Emmitte, Kyle A
- Lindsley, Craig W
- Jones, Carrie K
Producer: 20161108
In:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 41
Availability: No items available.
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80.
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Discovery of VU2957 (Valiglurax): An mGlu [electronic resource] by
- Panarese, Joseph D
- Engers, Darren W
- Wu, Yong-Jin
- Bronson, Joanne J
- Macor, John E
- Chun, Aspen
- Rodriguez, Alice L
- Felts, Andrew S
- Engers, Julie L
- Loch, Matthew T
- Emmitte, Kyle A
- Castelhano, Arlindo L
- Kates, Michael J
- Nader, Michael A
- Jones, Carrie K
- Blobaum, Anna L
- Conn, P Jeffrey
- Niswender, Colleen M
- Hopkins, Corey R
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Mar 2019
In:
ACS medicinal chemistry letters vol. 10
Availability: No items available.
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