Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold. [electronic resource]
Producer: 20130520Description: 7388-92 p. digitalISSN:- 1464-3405
- Allosteric Regulation -- drug effects
- Animals
- Binding Sites -- drug effects
- Dose-Response Relationship, Drug
- Drug Discovery
- Glycine -- analogs & derivatives
- Humans
- Models, Molecular
- Molecular Structure
- Rats
- Receptor, Metabotropic Glutamate 5
- Receptors, Metabotropic Glutamate -- chemistry
- Structure-Activity Relationship
- Sulfonamides -- chemical synthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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