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61.
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Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. [electronic resource] by
- Falgueyret, Jean-Pierre
- Desmarais, Sylvie
- Oballa, Renata
- Black, W Cameron
- Cromlish, Wanda
- Khougaz, Karine
- Lamontagne, Sonia
- Massé, Frederic
- Riendeau, Denis
- Toulmond, Sylvie
- Percival, M David
Producer: 20060209
In:
Journal of medicinal chemistry vol. 48
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62.
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Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors. [electronic resource] by
- St-Jacques, René
- Toulmond, Sylvie
- Auger, Anick
- Binkert, Christoph
- Cromlish, Wanda
- Fischli, Walter
- Harris, Jennifer
- Hess, Patrick
- Liu, Susana
- Riendeau, Denis
- Steiner, Beat
- Percival, M David
Producer: 20111227
In:
Journal of the renin-angiotensin-aldosterone system : JRAAS vol. 12
Availability: No items available.
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63.
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Is there a need for morphologic exam to detect relapse in AML if multi-parameter flow cytometry is employed? [electronic resource] by
- Zhou, Y
- Wood, B L
- Walter, R B
- Becker, P S
- Percival, M-E
- Bar, M
- Shaw, C
- Gardner, K
- Hendrie, P
- Abkowitz, J
- Appelbaum, F R
- Estey, E
Producer: 20180605
In:
Leukemia vol. 31
Availability: No items available.
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64.
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An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells. [electronic resource] by
- Falgueyret, Jean-Pierre
- Black, W Cameron
- Cromlish, Wanda
- Desmarais, Sylvie
- Lamontagne, Sonia
- Mellon, Christophe
- Riendeau, Denis
- Rodan, Sevgi
- Tawa, Paul
- Wesolowski, Gregg
- Bass, Kathryn E
- Venkatraman, Shankar
- Percival, M David
Producer: 20050919
In:
Analytical biochemistry vol. 335
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65.
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Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma. [electronic resource] by
- Deschamps, Kathleen
- Cromlish, Wanda
- Weicker, Sean
- Lamontagne, Sonia
- Huszar, Sarah L
- Gauthier, Jacques Yves
- Mudgett, John S
- Guimond, Alain
- Romand, Raymond
- Frossard, Nelly
- Percival, M David
- Slipetz, Deborah
- Tan, Christopher M
Producer: 20110908
In:
American journal of respiratory cell and molecular biology vol. 45
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66.
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A novel class of nonpeptidic biaryl inhibitors of human cathepsin K. [electronic resource] by
- Robichaud, Joël
- Oballa, Renata
- Prasit, Peppi
- Falgueyret, Jean-Pierre
- Percival, M David
- Wesolowski, Gregg
- Rodan, Sevgi B
- Kimmel, Donald
- Johnson, Colena
- Bryant, Cliff
- Venkatraman, Shankar
- Setti, Eduardo
- Mendonca, Rohan
- Palmer, James T
Producer: 20030909
In:
Journal of medicinal chemistry vol. 46
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67.
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Beta-substituted cyclohexanecarboxamide cathepsin K inhibitors: modification of the 1,2-disubstituted aromatic core. [electronic resource] by
- Robichaud, Joël
- Bayly, Christopher I
- Black, W Cameron
- Desmarais, Sylvie
- Léger, Serge
- Massé, Frédéric
- McKay, Daniel J
- Oballa, Renata M
- Pâquet, Julie
- Percival, M David
- Truchon, Jean-François
- Wesolowski, Gregg
- Crane, Sheldon N
Producer: 20070807
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
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68.
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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. [electronic resource] by
- Black, W Cameron
- Bayly, Christopher I
- Davis, Dana E
- Desmarais, Sylvie
- Falgueyret, Jean-Pierre
- Léger, Serge
- Li, Chun Sing
- Massé, Frédéric
- McKay, Daniel J
- Palmer, James T
- Percival, M David
- Robichaud, Joël
- Tsou, Nancy
- Zamboni, Robert
Producer: 20051223
In:
Bioorganic & medicinal chemistry letters vol. 15
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69.
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A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo. [electronic resource] by
- Zhang, Jun
- Preda, Dorin V
- Vasquez, Kristine O
- Morin, Jeff
- Delaney, Jeannine
- Bao, Bagna
- Percival, M David
- Xu, Daigen
- McKay, Dan
- Klimas, Michael
- Bednar, Bohumil
- Sur, Cyrille
- Gao, David Z
- Madden, Karen
- Yared, Wael
- Rajopadhye, Milind
- Peterson, Jeffrey D
Producer: 20121106
In:
American journal of physiology. Renal physiology vol. 303
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70.
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The identification of potent, selective, and bioavailable cathepsin S inhibitors. [electronic resource] by
- Gauthier, Jacques Yves
- Black, W Cameron
- Courchesne, Isabelle
- Cromlish, Wanda
- Desmarais, Sylvie
- Houle, Robert
- Lamontagne, Sonia
- Li, Chun Sing
- Massé, Frédéric
- McKay, Daniel J
- Ouellet, Marc
- Robichaud, Joël
- Truchon, Jean-François
- Truong, Vouy-Linh
- Wang, Qingping
- Percival, M David
Producer: 20071120
In:
Bioorganic & medicinal chemistry letters vol. 17
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71.
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Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores. [electronic resource] by
- Funicello, Marcella
- Novelli, Michela
- Ragni, Maurizio
- Vottari, Teresa
- Cocuzza, Cesare
- Soriano-Lopez, Joaquin
- Chiellini, Chiara
- Boschi, Federico
- Marzola, Pasquina
- Masiello, Pellegrino
- Saftig, Paul
- Santini, Ferruccio
- St-Jacques, Rene
- Desmarais, Sylvie
- Morin, Nicolas
- Mancini, Joseph
- Percival, M David
- Pinchera, Aldo
- Maffei, Margherita
Producer: 20100312
In:
PloS one vol. 2
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72.
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The discovery and synthesis of potent zwitterionic inhibitors of renin. [electronic resource] by
- Aspiotis, Renee
- Chen, Austin
- Cauchon, Elizabeth
- Dubé, Daniel
- Falgueyret, Jean-Pierre
- Gagné, Sébastien
- Gallant, Michel
- Grimm, Erich L
- Houle, Robert
- Juteau, Hélène
- Lacombe, Patrick
- Laliberté, Sébastien
- Lévesque, Jean-François
- MacDonald, Dwight
- McKay, Dan
- Percival, M David
- Roy, Patrick
- Soisson, Stephen M
- Wu, Tom
Producer: 20110719
In:
Bioorganic & medicinal chemistry letters vol. 21
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73.
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Mitoxantrone, etoposide and cytarabine following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: a phase 1/2 study. [electronic resource] by
- Halpern, A B
- Othus, M
- Huebner, E M
- Buckley, S A
- Pogosova-Agadjanyan, E L
- Orlowski, K F
- Scott, B L
- Becker, P S
- Hendrie, P C
- Chen, T L
- Percival, M-E M
- Estey, E H
- Stirewalt, D L
- Walter, R B
Producer: 20171215
In:
Leukemia vol. 31
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74.
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Design and synthesis of potent, isoxazole-containing renin inhibitors. [electronic resource] by
- Fournier, Pierre-André
- Arbour, Mélissa
- Cauchon, Elizabeth
- Chen, Austin
- Chefson, Amandine
- Ducharme, Yves
- Falgueyret, Jean-Pierre
- Gagné, Sébastien
- Grimm, Erich
- Han, Yongxin
- Houle, Robert
- Lacombe, Patrick
- Lévesque, Jean-François
- MacDonald, Dwight
- Mackay, Bruce
- McKay, Dan
- Percival, M David
- Ramtohul, Yeeman
- St-Jacques, René
- Toulmond, Sylvie
Producer: 20120918
In:
Bioorganic & medicinal chemistry letters vol. 22
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75.
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Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis. [electronic resource] by
- Robichaud, Jöel
- Black, W Cameron
- Thérien, Michel
- Paquet, Julie
- Oballa, Renata M
- Bayly, Christopher I
- McKay, Daniel J
- Wang, Qingping
- Isabel, Elise
- Léger, Serge
- Mellon, Christophe
- Kimmel, Donald B
- Wesolowski, Gregg
- Percival, M David
- Massé, Fréderic
- Desmarais, Sylvie
- Falgueyret, Jean-Pierre
- Crane, Sheldon N
Producer: 20081113
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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76.
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Identification of a potent and selective non-basic cathepsin K inhibitor. [electronic resource] by
- Li, Chun Sing
- Deschenes, Denis
- Desmarais, Sylvie
- Falgueyret, Jean-Pierre
- Gauthier, Jacques Yves
- Kimmel, Donald B
- Léger, Serge
- Massé, Frédéric
- McGrath, Mary E
- McKay, Daniel J
- Percival, M David
- Riendeau, Denis
- Rodan, Sevgi B
- Thérien, Michel
- Truong, Vouy-Linh
- Wesolowski, Gregg
- Zamboni, Robert
- Black, W Cameron
Producer: 20060719
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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77.
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Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. [electronic resource] by
- Baugh, Mark
- Black, Darcey
- Westwood, Paul
- Kinghorn, Emma
- McGregor, Kieran
- Bruin, John
- Hamilton, William
- Dempster, Maureen
- Claxton, Christopher
- Cai, Jiaqiang
- Bennett, Jonathan
- Long, Clive
- McKinnon, Heather
- Vink, Paul
- den Hoed, Leontien
- Gorecka, Monika
- Vora, Kalpit
- Grant, Ethan
- Percival, M David
- Boots, A Mieke H
- van Lierop, Marie-José
Producer: 20110801
In:
Journal of autoimmunity vol. 36
Availability: No items available.
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78.
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. [electronic resource] by
- Riendeau, D
- Percival, M D
- Boyce, S
- Brideau, C
- Charleson, S
- Cromlish, W
- Ethier, D
- Evans, J
- Falgueyret, J P
- Ford-Hutchinson, A W
- Gordon, R
- Greig, G
- Gresser, M
- Guay, J
- Kargman, S
- Léger, S
- Mancini, J A
- O'Neill, G
- Ouellet, M
- Rodger, I W
- Thérien, M
- Wang, Z
- Webb, J K
- Wong, E
- Chan, C C
Producer: 19970729
In:
British journal of pharmacology vol. 121
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79.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. [electronic resource] by
- Chan, C C
- Boyce, S
- Brideau, C
- Charleson, S
- Cromlish, W
- Ethier, D
- Evans, J
- Ford-Hutchinson, A W
- Forrest, M J
- Gauthier, J Y
- Gordon, R
- Gresser, M
- Guay, J
- Kargman, S
- Kennedy, B
- Leblanc, Y
- Leger, S
- Mancini, J
- O'Neill, G P
- Ouellet, M
- Patrick, D
- Percival, M D
- Perrier, H
- Prasit, P
- Rodger, I
Producer: 19990818
In:
The Journal of pharmacology and experimental therapeutics vol. 290
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80.
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor. [electronic resource] by
- Prasit, P
- Wang, Z
- Brideau, C
- Chan, C C
- Charleson, S
- Cromlish, W
- Ethier, D
- Evans, J F
- Ford-Hutchinson, A W
- Gauthier, J Y
- Gordon, R
- Guay, J
- Gresser, M
- Kargman, S
- Kennedy, B
- Leblanc, Y
- Léger, S
- Mancini, J
- O'Neill, G P
- Ouellet, M
- Percival, M D
- Perrier, H
- Riendeau, D
- Rodger, I
- Zamboni, R
Producer: 19991014
In:
Bioorganic & medicinal chemistry letters vol. 9
Availability: No items available.
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