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281.
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The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). [electronic resource] by
- Heffron, Timothy P
- Heald, Robert A
- Ndubaku, Chudi
- Wei, BinQing
- Augistin, Martin
- Do, Steven
- Edgar, Kyle
- Eigenbrot, Charles
- Friedman, Lori
- Gancia, Emanuela
- Jackson, Philip S
- Jones, Graham
- Kolesnikov, Aleksander
- Lee, Leslie B
- Lesnick, John D
- Lewis, Cristina
- McLean, Neville
- Mörtl, Mario
- Nonomiya, Jim
- Pang, Jodie
- Price, Steve
- Prior, Wei Wei
- Salphati, Laurent
- Sideris, Steve
- Staben, Steven T
- Steinbacher, Stefan
- Tsui, Vickie
- Wallin, Jeffrey
- Sampath, Deepak
- Olivero, Alan G
Producer: 20160712
In:
Journal of medicinal chemistry vol. 59
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282.
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Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo. [electronic resource] by
- Lopez, Salvatore
- Cocco, Emiliano
- Black, Jonathan
- Bellone, Stefania
- Bonazzoli, Elena
- Predolini, Federica
- Ferrari, Francesca
- Schwab, Carlton L
- English, Diana P
- Ratner, Elena
- Silasi, Dan-Arin
- Azodi, Masoud
- Schwartz, Peter E
- Terranova, Corrado
- Angioli, Roberto
- Santin, Alessandro D
Producer: 20160906
In:
Molecular cancer therapeutics vol. 14
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283.
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HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. [electronic resource] by
- Ramírez, Alberto
- Boulaiz, Houria
- Morata-Tarifa, Cynthia
- Perán, Macarena
- Jiménez, Gema
- Picon-Ruiz, Manuel
- Agil, Ahmad
- Cruz-López, Olga
- Conejo-García, Ana
- Campos, Joaquín M
- Sánchez, Ana
- García, María A
- Marchal, Juan A
Producer: 20150422
In:
Oncotarget vol. 5
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284.
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The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia. [electronic resource] by
- McElligott, Anthony M
- Maginn, Elaina N
- Greene, Lisa M
- McGuckin, Siobhan
- Hayat, Amjad
- Browne, Paul V
- Butini, Stefania
- Campiani, Giuseppe
- Catherwood, Mark A
- Vandenberghe, Elisabeth
- Williams, D Clive
- Zisterer, Daniela M
- Lawler, Mark
Producer: 20091123
In:
Cancer research vol. 69
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285.
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286.
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287.
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PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. [electronic resource] by
- Zhen, Gehua
- Kim, Yun Tai
- Li, Rung-chi
- Yocum, Jennifer
- Kapoor, Nidhi
- Langer, John
- Dobrowolski, Peter
- Maruyama, Takayuki
- Narumiya, Shuh
- Doré, Sylvain
Producer: 20121129
In:
Neurobiology of aging vol. 33
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288.
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Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. [electronic resource] by
- Donnell, Andrew F
- Michoud, Christophe
- Rupert, Kenneth C
- Han, Xiaochun
- Aguilar, Douglas
- Frank, Karl B
- Fretland, Adrian J
- Gao, Lin
- Goggin, Barry
- Hogg, J Heather
- Hong, Kyoungja
- Janson, Cheryl A
- Kester, Robert F
- Kong, Norman
- Le, Kang
- Li, Shirley
- Liang, Weiling
- Lombardo, Louis J
- Lou, Yan
- Lukacs, Christine M
- Mischke, Steven
- Moliterni, John A
- Polonskaia, Ann
- Schutt, Andrew D
- Solis, Dave S
- Specian, Anthony
- Taylor, Robert T
- Weisel, Martin
- Remiszewski, Stacy W
Producer: 20140310
In:
Journal of medicinal chemistry vol. 56
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289.
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Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K). [electronic resource] by
- Castanedo, Georgette M
- Blaquiere, Nicole
- Beresini, Maureen
- Bravo, Brandon
- Brightbill, Hans
- Chen, Jacob
- Cui, Hai-Feng
- Eigenbrot, Charles
- Everett, Christine
- Feng, Jianwen
- Godemann, Robert
- Gogol, Emily
- Hymowitz, Sarah
- Johnson, Adam
- Kayagaki, Nobuhiko
- Kohli, Pawan Bir
- Knüppel, Kathleen
- Kraemer, Joachim
- Krüger, Susan
- Loke, Pui
- McEwan, Paul
- Montalbetti, Christian
- Roberts, David A
- Smith, Myron
- Steinbacher, Stefan
- Sujatha-Bhaskar, Swathi
- Takahashi, Ryan
- Wang, Xiaolu
- Wu, Lawren C
- Zhang, Yamin
- Staben, Steven T
Producer: 20170704
In:
Journal of medicinal chemistry vol. 60
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290.
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291.
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292.
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Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo. [electronic resource] by
- Lopez, Salvatore
- Schwab, Carlton L
- Cocco, Emiliano
- Bellone, Stefania
- Bonazzoli, Elena
- English, Diana P
- Schwartz, Peter E
- Rutherford, Thomas
- Angioli, Roberto
- Santin, Alessandro D
Producer: 20150129
In:
Gynecologic oncology vol. 135
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293.
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Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations. [electronic resource] by
- Zumsteg, Zachary S
- Morse, Natasha
- Krigsfeld, Gabriel
- Gupta, Gaorav
- Higginson, Daniel S
- Lee, Nancy Y
- Morris, Luc
- Ganly, Ian
- Shiao, Stephan L
- Powell, Simon N
- Chung, Christine H
- Scaltriti, Maurizio
- Baselga, José
Producer: 20161230
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 22
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294.
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295.
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Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer. [electronic resource] by
- Sato, Hiroki
- Yamamoto, Hiromasa
- Sakaguchi, Masakiyo
- Shien, Kazuhiko
- Tomida, Shuta
- Shien, Tadahiko
- Ikeda, Hirokuni
- Hatono, Minami
- Torigoe, Hidejiro
- Namba, Kei
- Yoshioka, Takahiro
- Kurihara, Eisuke
- Ogoshi, Yusuke
- Takahashi, Yuta
- Soh, Junichi
- Toyooka, Shinichi
Producer: 20181012
In:
Cancer science vol. 109
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296.
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297.
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