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	141.	Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold. [electronic resource] by Rodriguez, Alice L Zhou, Ya Williams, Richard Weaver, C David Vinson, Paige N Dawson, Eric S Steckler, Thomas Lavreysen, Hilde Mackie, Claire Bartolomé, José M Macdonald, Gregor J Daniels, J Scott Niswender, Colleen M Jones, Carrie K Conn, P Jeffrey Lindsley, Craig W Stauffer, Shaun R Producer: 20130520 In: Bioorganic & medicinal chemistry letters vol. 22 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	142.	Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice. [electronic resource] by Pancani, Tristano Foster, Daniel J Moehle, Mark S Bichell, Terry Jo Bradley, Emma Bridges, Thomas M Klar, Rebecca Poslusney, Mike Rook, Jerri M Daniels, J Scott Niswender, Colleen M Jones, Carrie K Wood, Michael R Bowman, Aaron B Lindsley, Craig W Xiang, Zixiu Conn, P Jeffrey Producer: 20160229 In: Proceedings of the National Academy of Sciences of the United States of America vol. 112 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	143.	Discovery of VU6005649, a CNS Penetrant mGlu [electronic resource] by Abe, Masahito Seto, Mabel Gogliotti, Rocco G Loch, Matthew T Bollinger, Katrina A Chang, Sichen Engelberg, Eileen M Luscombe, Vincent B Harp, Joel M Bubser, Michael Engers, Darren W Jones, Carrie K Rodriguez, Alice L Blobaum, Anna L Conn, P Jeffrey Niswender, Colleen M Lindsley, Craig W Publication details: ACS medicinal chemistry letters Oct 2017 In: ACS medicinal chemistry letters vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	144.	The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. [electronic resource] by Jones, Carrie K Bubser, Michael Thompson, Analisa D Dickerson, Jonathan W Turle-Lorenzo, Nathalie Amalric, Marianne Blobaum, Anna L Bridges, Thomas M Morrison, Ryan D Jadhav, Satyawan Engers, Darren W Italiano, Kimberly Bode, Jacob Daniels, J Scott Lindsley, Craig W Hopkins, Corey R Conn, P Jeffrey Niswender, Colleen M Producer: 20120406 In: The Journal of pharmacology and experimental therapeutics vol. 340 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	145.	Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions. [electronic resource] by Blobaum, Anna L Bridges, Thomas M Byers, Frank W Turlington, Mark L Mattmann, Margrith E Morrison, Ryan D Mackie, Claire Lavreysen, Hilde Bartolomé, José M Macdonald, Gregor J Steckler, Thomas Jones, Carrie K Niswender, Colleen M Conn, P Jeffrey Lindsley, Craig W Stauffer, Shaun R Daniels, J Scott Producer: 20140624 In: Drug metabolism and disposition: the biological fate of chemicals vol. 41 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	146.	State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects. [electronic resource] by Gould, Robert W Nedelcovych, Michael T Gong, Xuewen Tsai, Erica Bubser, Michael Bridges, Thomas M Wood, Michael R Duggan, Mark E Brandon, Nicholas J Dunlop, John Wood, Michael W Ivarsson, Magnus Noetzel, Meredith J Daniels, J Scott Niswender, Colleen M Lindsley, Craig W Conn, P Jeffrey Jones, Carrie K Producer: 20161007 In: Neuropharmacology vol. 102 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	147.	Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. [electronic resource] by Melancon, Bruce J Gogliotti, Rocco D Tarr, James C Saleh, Sam A Chauder, Brian A Lebois, Evan P Cho, Hyekyung P Utley, Thomas J Sheffler, Douglas J Bridges, Thomas M Morrison, Ryan D Daniels, J Scott Niswender, Colleen M Conn, P Jeffrey Lindsley, Craig W Wood, Michael R Producer: 20120910 In: Bioorganic & medicinal chemistry letters vol. 22 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	148.	M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product. [electronic resource] by Garcia, Raphael Caio Tamborelli Dati, Livia Mendonça Munhoz Torres, Larissa Helena da Silva, Mariana Aguilera Alencar Udo, Mariana Sayuri Berto Abdalla, Fernando Maurício Francis da Costa, José Luiz Gorjão, Renata Afeche, Solange Castro Yonamine, Mauricio Niswender, Colleen M Conn, P Jeffrey Camarini, Rosana Sandoval, Maria Regina Lopes Marcourakis, Tania Producer: 20160928 In: Scientific reports vol. 5 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	149.	Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe. [electronic resource] by Weaver, C David Sheffler, Douglas J Lewis, L Michelle Bridges, Thomas M Williams, Richard Nalywajko, Natalia T Kennedy, J Phillip Mulder, Matthew M Jadhav, Satyawan Aldrich, Leslie A Jones, Carrie K Marlo, Joy E Niswender, Colleen M Mock, Matthew M Zheng, Fang Conn, P Jeffrey Lindsley, Craig W Producer: 20100916 In: Current topics in medicinal chemistry vol. 9 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	150.	Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency. [electronic resource] by Turlington, Mark Noetzel, Meredith J Bridges, Thomas M Vinson, Paige N Steckler, Thomas Lavreysen, Hilde Mackie, Claire Bartolomé-Nebreda, José M Conde-Ceide, Susana Tong, Han Min Macdonald, Gregor J Daniels, J Scott Jones, Carrie K Niswender, Colleen M Conn, P Jeffrey Lindsley, Craig W Stauffer, Shaun R Producer: 20150305 In: Bioorganic & medicinal chemistry letters vol. 24 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	151.	VU6010608, a Novel mGlu [electronic resource] by Reed, Carson W McGowan, Kevin M Spearing, Paul K Stansley, Branden J Roenfanz, Hanna F Engers, Darren W Rodriguez, Alice L Engelberg, Eileen M Luscombe, Vincent B Loch, Matthew T Remke, Daniel H Rook, Jerri M Blobaum, Anna L Conn, P Jeffrey Niswender, Colleen M Lindsley, Craig W Publication details: ACS medicinal chemistry letters Dec 2017 In: ACS medicinal chemistry letters vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	152.	Design and Synthesis of [electronic resource] by Engers, Julie L Bollinger, Katrina A Weiner, Rebecca L Rodriguez, Alice L Long, Madeline F Breiner, Megan M Chang, Sichen Bollinger, Sean R Bubser, Michael Jones, Carrie K Morrison, Ryan D Bridges, Thomas M Blobaum, Anna L Niswender, Colleen M Conn, P Jeffrey Emmitte, Kyle A Lindsley, Craig W Publication details: ACS medicinal chemistry letters Sep 2017 In: ACS medicinal chemistry letters vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	153.	VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy. [electronic resource] by Nickols, Hilary Highfield Yuh, Joannes P Gregory, Karen J Morrison, Ryan D Bates, Brittney S Stauffer, Shaun R Emmitte, Kyle A Bubser, Michael Peng, Weimin Nedelcovych, Michael T Thompson, Analisa Lv, Xiaohui Xiang, Zixiu Daniels, J Scott Niswender, Colleen M Lindsley, Craig W Jones, Carrie K Conn, P Jeffrey Producer: 20160315 In: The Journal of pharmacology and experimental therapeutics vol. 356 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	154.	Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. [electronic resource] by Le, Uyen Melancon, Bruce J Bridges, Thomas M Vinson, Paige N Utley, Thomas J Lamsal, Atin Rodriguez, Alice L Venable, Daryl Sheffler, Douglas J Jones, Carrie K Blobaum, Anna L Wood, Michael R Daniels, J Scott Conn, P Jeffrey Niswender, Colleen M Lindsley, Craig W Hopkins, Corey R Producer: 20130528 In: Bioorganic & medicinal chemistry letters vol. 23 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	155.	Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. [electronic resource] by Niswender, Colleen M Johnson, Kari A Weaver, C David Jones, Carrie K Xiang, Zixiu Luo, Qingwei Rodriguez, Alice L Marlo, Joy E de Paulis, Tomas Thompson, Analisa D Days, Emily L Nalywajko, Tasha Austin, Cheryl A Williams, Michael Baxter Ayala, Jennifer E Williams, Richard Lindsley, Craig W Conn, P Jeffrey Producer: 20081117 In: Molecular pharmacology vol. 74 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	156.	Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. [electronic resource] by Jones, Carrie K Engers, Darren W Thompson, Analisa D Field, Julie R Blobaum, Anna L Lindsley, Stacey R Zhou, Ya Gogliotti, Rocco D Jadhav, Satyawan Zamorano, Rocio Bogenpohl, Jim Smith, Yoland Morrison, Ryan Daniels, J Scott Weaver, C David Conn, P Jeffrey Lindsley, Craig W Niswender, Colleen M Hopkins, Corey R Producer: 20120207 In: Journal of medicinal chemistry vol. 54 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	157.	Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. [electronic resource] by Tarr, James C Turlington, Mark L Reid, Paul R Utley, Thomas J Sheffler, Douglas J Cho, Hyekyung P Klar, Rebecca Pancani, Tristano Klein, Michael T Bridges, Thomas M Morrison, Ryan D Blobaum, Anna L Xiang, Zixui Daniels, J Scott Niswender, Colleen M Conn, P Jeffrey Wood, Michael R Lindsley, Craig W Producer: 20130809 In: ACS chemical neuroscience vol. 3 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	158.	Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. [electronic resource] by Wood, Michael R Noetzel, Meredith J Tarr, James C Rodriguez, Alice L Lamsal, Atin Chang, Sichen Foster, Jarrett J Smith, Emery Chase, Peter Hodder, Peter S Engers, Darren W Niswender, Colleen M Brandon, Nicholas J Wood, Michael W Duggan, Mark E Conn, P Jeffrey Bridges, Thomas M Lindsley, Craig W Producer: 20170829 In: Bioorganic & medicinal chemistry letters vol. 26 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	159.	A Novel M [electronic resource] by Rook, Jerri M Bertron, Jeanette L Cho, Hyekyung P Garcia-Barrantes, Pedro M Moran, Sean P Maksymetz, James T Nance, Kellie D Dickerson, Jonathan W Remke, Daniel H Chang, Sichen Harp, Joel M Blobaum, Anna L Niswender, Colleen M Jones, Carrie K Stauffer, Shaun R Conn, P Jeffrey Lindsley, Craig W Producer: 20191211 In: ACS chemical neuroscience vol. 9 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	160.	Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. [electronic resource] by Marlo, Joy E Niswender, Colleen M Days, Emily L Bridges, Thomas M Xiang, Yun Rodriguez, Alice L Shirey, Jana K Brady, Ashley E Nalywajko, Tasha Luo, Qingwei Austin, Cheryl A Williams, Michael Baxter Kim, Kwangho Williams, Richard Orton, Darren Brown, H Alex Lindsley, Craig W Weaver, C David Conn, P Jeffrey Producer: 20090316 In: Molecular pharmacology vol. 75 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)

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Your search returned 193 results.