Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. [electronic resource]
Producer: 19990401Description: 1117-24 p. digitalISSN:- 0022-3565
- Acetates -- pharmacology
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Arachidonic Acid -- pharmacology
- Cell Line
- Cloning, Molecular
- Cricetinae
- Group II Phospholipases A2
- Guinea Pigs
- Humans
- Indoles -- pharmacology
- Keto Acids
- Male
- Mesocricetus
- Mice
- Mice, Transgenic
- Muscle, Smooth -- drug effects
- Phospholipases A -- antagonists & inhibitors
- Phospholipases A2
- Pleura -- drug effects
- Rabbits
- Rats
- Recombinant Proteins -- biosynthesis
- Thromboxane A2 -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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