Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. [electronic resource]
Producer: 19990325Description: 2416-24 p. digitalISSN:- 0270-7306
- Animals
- Caspase 1 -- metabolism
- Cell Line
- DNA-Binding Proteins -- genetics
- Enzyme Induction
- Fibroblasts -- cytology
- Humans
- Interferon-alpha -- metabolism
- Interferon-gamma -- metabolism
- Intracellular Signaling Peptides and Proteins
- Janus Kinase 1
- Membrane Proteins
- Mice
- Mutagenesis
- Phenotype
- Phosphorylation
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatases -- genetics
- Protein-Tyrosine Kinases -- metabolism
- Receptor, Interferon alpha-beta
- Receptors, Interferon -- metabolism
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- STAT1 Transcription Factor
- STAT2 Transcription Factor
- Signal Transduction
- Trans-Activators -- genetics
- Interferon gamma Receptor
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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