Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. [electronic resource]
Producer: 19990219Description: 567-77 p. digitalISSN:- 0006-2952
- Adenocarcinoma
- Antineoplastic Agents -- toxicity
- Carcinoma, Squamous Cell
- Cell Division -- drug effects
- Colonic Neoplasms
- Drug Resistance, Multiple
- Drug Synergism
- Folic Acid -- pharmacology
- Folic Acid Antagonists -- toxicity
- Glutamates -- toxicity
- Head and Neck Neoplasms
- Humans
- Hydroxymethyl and Formyl Transferases -- antagonists & inhibitors
- Kinetics
- Lung Neoplasms
- Phosphoribosylglycinamide Formyltransferase
- Pyrimidines -- toxicity
- Trimetrexate -- toxicity
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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