Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.

Faessel, H M

Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. [electronic resource] - Biochemical pharmacology Mar 1999 - 567-77 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-2952

10.1016/s0006-2952(98)00315-3 doi


Adenocarcinoma
Antineoplastic Agents--toxicity
Carcinoma, Squamous Cell
Cell Division--drug effects
Colonic Neoplasms
Drug Resistance, Multiple
Drug Synergism
Folic Acid--pharmacology
Folic Acid Antagonists--toxicity
Glutamates--toxicity
Head and Neck Neoplasms
Humans
Hydroxymethyl and Formyl Transferases--antagonists & inhibitors
Kinetics
Lung Neoplasms
Phosphoribosylglycinamide Formyltransferase
Pyrimidines--toxicity
Trimetrexate--toxicity
Tumor Cells, Cultured