Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. [electronic resource]
Producer: 19990301Description: 133-8 p. digitalISSN:- 0027-8424
- Alendronate -- pharmacology
- Animals
- Bone Resorption -- metabolism
- Cell Differentiation -- drug effects
- Cells, Cultured
- Cholesterol -- biosynthesis
- Clodronic Acid -- pharmacology
- Diterpenes -- pharmacology
- Enzyme Activation -- drug effects
- Farnesol -- pharmacology
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Lovastatin -- pharmacology
- Mevalonic Acid -- metabolism
- Mice
- Osteoclasts -- cytology
- Protein Kinases -- metabolism
- Rabbits
- Skull -- metabolism
- Squalene -- pharmacology
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Publication Type: Journal Article
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