Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher, J E
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Jan 1999 - 133-8 p. digital
Publication Type: Journal Article
0027-8424
10.1073/pnas.96.1.133 doi
Alendronate--pharmacology
Animals
Bone Resorption--metabolism
Cell Differentiation--drug effects
Cells, Cultured
Cholesterol--biosynthesis
Clodronic Acid--pharmacology
Diterpenes--pharmacology
Enzyme Activation--drug effects
Farnesol--pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Lovastatin--pharmacology
Mevalonic Acid--metabolism
Mice
Osteoclasts--cytology
Protein Kinases--metabolism
Rabbits
Skull--metabolism
Squalene--pharmacology
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Jan 1999 - 133-8 p. digital
Publication Type: Journal Article
0027-8424
10.1073/pnas.96.1.133 doi
Alendronate--pharmacology
Animals
Bone Resorption--metabolism
Cell Differentiation--drug effects
Cells, Cultured
Cholesterol--biosynthesis
Clodronic Acid--pharmacology
Diterpenes--pharmacology
Enzyme Activation--drug effects
Farnesol--pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Lovastatin--pharmacology
Mevalonic Acid--metabolism
Mice
Osteoclasts--cytology
Protein Kinases--metabolism
Rabbits
Skull--metabolism
Squalene--pharmacology