Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen. [electronic resource]
Producer: 19981007Description: 240-8 p. digitalISSN:- 0003-9861
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- Diclofenac -- metabolism
- Enzyme Activation -- drug effects
- Escherichia coli -- genetics
- Humans
- Hydroxylation
- Ibuprofen -- metabolism
- Mixed Function Oxygenases -- genetics
- Mutagenesis, Site-Directed
- Protein Binding -- drug effects
- Recombinant Fusion Proteins -- genetics
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- antagonists & inhibitors
- Substrate Specificity -- genetics
- Tolbutamide -- metabolism
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Publication Type: Journal Article
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