Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. [electronic resource]
Producer: 19980803Description: 2806-18 p. digitalISSN:- 0022-2623
- 3C Viral Proteases
- Animals
- Antiviral Agents -- chemical synthesis
- Binding Sites
- Cell Line, Transformed
- Crystallography, X-Ray
- Cysteine Endopeptidases -- chemistry
- Cysteine Proteinase Inhibitors -- chemical synthesis
- Drug Design
- Drug Stability
- HeLa Cells
- Humans
- Oligopeptides -- chemical synthesis
- Protein Conformation
- Rats
- Rats, Sprague-Dawley
- Rhinovirus -- drug effects
- Structure-Activity Relationship
- Viral Proteins
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Publication Type: Comparative Study; Journal Article
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