Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.

Dragovich, P S

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. [electronic resource] - Journal of medicinal chemistry Jul 1998 - 2806-18 p. digital

Publication Type: Comparative Study; Journal Article

0022-2623

10.1021/jm980068d doi


3C Viral Proteases
Animals
Antiviral Agents--chemical synthesis
Binding Sites
Cell Line, Transformed
Crystallography, X-Ray
Cysteine Endopeptidases--chemistry
Cysteine Proteinase Inhibitors--chemical synthesis
Drug Design
Drug Stability
HeLa Cells
Humans
Oligopeptides--chemical synthesis
Protein Conformation
Rats
Rats, Sprague-Dawley
Rhinovirus--drug effects
Structure-Activity Relationship
Viral Proteins