Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. [electronic resource]
Producer: 19980624Description: 2040-6 p. digitalISSN:- 0022-2623
- Animals
- Cattle
- DNA Polymerase I -- antagonists & inhibitors
- DNA Polymerase II -- antagonists & inhibitors
- DNA Polymerase III -- antagonists & inhibitors
- DNA Polymerase beta -- antagonists & inhibitors
- DNA Polymerase gamma
- DNA-Directed DNA Polymerase -- isolation & purification
- Enzyme Inhibitors -- chemical synthesis
- HIV Reverse Transcriptase -- antagonists & inhibitors
- HeLa Cells
- Hepatitis B -- enzymology
- Hepatitis B Virus, Duck -- enzymology
- Humans
- Kinetics
- Nucleic Acid Synthesis Inhibitors
- Organophosphates -- chemical synthesis
- Placenta -- enzymology
- Pyrimidine Nucleosides -- chemical synthesis
- Reverse Transcriptase Inhibitors -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Comparative Study; Journal Article
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