Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.

von Janta-Lipinski, M

Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. [electronic resource] - Journal of medicinal chemistry Jun 1998 - 2040-6 p. digital

Publication Type: Comparative Study; Journal Article

0022-2623

10.1021/jm9704210 doi


Animals
Cattle
DNA Polymerase I--antagonists & inhibitors
DNA Polymerase II--antagonists & inhibitors
DNA Polymerase III--antagonists & inhibitors
DNA Polymerase beta--antagonists & inhibitors
DNA Polymerase gamma
DNA-Directed DNA Polymerase--isolation & purification
Enzyme Inhibitors--chemical synthesis
HIV Reverse Transcriptase--antagonists & inhibitors
HeLa Cells
Hepatitis B--enzymology
Hepatitis B Virus, Duck--enzymology
Humans
Kinetics
Nucleic Acid Synthesis Inhibitors
Organophosphates--chemical synthesis
Placenta--enzymology
Pyrimidine Nucleosides--chemical synthesis
Reverse Transcriptase Inhibitors--chemical synthesis
Stereoisomerism
Structure-Activity Relationship