Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha. [electronic resource]
Producer: 19980514Description: 1139-47 p. digitalISSN:- 0022-1767
- Antigens, Neoplasm -- biosynthesis
- Cell Line
- Cytotoxicity, Immunologic -- genetics
- DNA, Complementary -- genetics
- Dendritic Cells -- immunology
- Epitopes, T-Lymphocyte -- immunology
- Humans
- Immunophenotyping
- Interferon-gamma -- biosynthesis
- Interleukin-12 -- biosynthesis
- Luciferases -- biosynthesis
- MART-1 Antigen
- Melanoma -- immunology
- Membrane Glycoproteins -- genetics
- Monocytes -- immunology
- Mutagenesis, Insertional -- immunology
- Neoplasm Proteins -- genetics
- Peptides -- immunology
- T-Lymphocytes, Cytotoxic -- immunology
- Th1 Cells -- metabolism
- Transfection -- immunology
- Tumor Cells, Cultured
- Vaccines, DNA -- immunology
- gp100 Melanoma Antigen
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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