Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha.

Tüting, T

Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 1998 - 1139-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-1767


Antigens, Neoplasm--biosynthesis
Cell Line
Cytotoxicity, Immunologic--genetics
DNA, Complementary--genetics
Dendritic Cells--immunology
Epitopes, T-Lymphocyte--immunology
Humans
Immunophenotyping
Interferon-gamma--biosynthesis
Interleukin-12--biosynthesis
Luciferases--biosynthesis
MART-1 Antigen
Melanoma--immunology
Membrane Glycoproteins--genetics
Monocytes--immunology
Mutagenesis, Insertional--immunology
Neoplasm Proteins--genetics
Peptides--immunology
T-Lymphocytes, Cytotoxic--immunology
Th1 Cells--metabolism
Transfection--immunology
Tumor Cells, Cultured
Vaccines, DNA--immunology
gp100 Melanoma Antigen