Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. [electronic resource]
Producer: 19980514Description: 5528-35 p. digitalISSN:- 0006-2960
- Cytosine -- metabolism
- Deoxyadenosines -- metabolism
- Deoxycytidine -- analogs & derivatives
- Electron Spin Resonance Spectroscopy
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- chemistry
- Enzyme Stability -- drug effects
- Fluorides -- metabolism
- Free Radicals -- metabolism
- Lactobacillus -- enzymology
- Peptides -- metabolism
- Protein Denaturation
- Ribonucleotide Reductases -- antagonists & inhibitors
- Spectrophotometry, Ultraviolet
- Sulfhydryl Compounds -- pharmacology
- Vitamin B 12 -- metabolism
- Gemcitabine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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