Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation.
Silva, D J
Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. [electronic resource] - Biochemistry Apr 1998 - 5528-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi972934e doi
Cytosine--metabolism
Deoxyadenosines--metabolism
Deoxycytidine--analogs & derivatives
Electron Spin Resonance Spectroscopy
Enzyme Activation--drug effects
Enzyme Inhibitors--chemistry
Enzyme Stability--drug effects
Fluorides--metabolism
Free Radicals--metabolism
Lactobacillus--enzymology
Peptides--metabolism
Protein Denaturation
Ribonucleotide Reductases--antagonists & inhibitors
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds--pharmacology
Vitamin B 12--metabolism
Gemcitabine
Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. [electronic resource] - Biochemistry Apr 1998 - 5528-35 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi972934e doi
Cytosine--metabolism
Deoxyadenosines--metabolism
Deoxycytidine--analogs & derivatives
Electron Spin Resonance Spectroscopy
Enzyme Activation--drug effects
Enzyme Inhibitors--chemistry
Enzyme Stability--drug effects
Fluorides--metabolism
Free Radicals--metabolism
Lactobacillus--enzymology
Peptides--metabolism
Protein Denaturation
Ribonucleotide Reductases--antagonists & inhibitors
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds--pharmacology
Vitamin B 12--metabolism
Gemcitabine