A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2. [electronic resource]
Producer: 19980323Description: 4188-96 p. digitalISSN:- 0021-9258
- Animals
- Apolipoprotein C-II
- Apolipoproteins C -- genetics
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cells, Cultured
- DNA Footprinting
- DNA-Binding Proteins -- analysis
- Gene Expression Regulation -- genetics
- Genes, Reporter -- genetics
- Hepatocyte Nuclear Factor 4
- Humans
- Liver -- chemistry
- Molecular Sequence Data
- Nuclear Proteins -- metabolism
- Phosphoproteins -- genetics
- Promoter Regions, Genetic -- genetics
- Rats
- Transcription Factors -- genetics
- Transcriptional Activation -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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