A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2.
Vorgia, P
A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2. [electronic resource] - The Journal of biological chemistry Feb 1998 - 4188-96 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.273.7.4188 doi
Animals
Apolipoprotein C-II
Apolipoproteins C--genetics
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cells, Cultured
DNA Footprinting
DNA-Binding Proteins--analysis
Gene Expression Regulation--genetics
Genes, Reporter--genetics
Hepatocyte Nuclear Factor 4
Humans
Liver--chemistry
Molecular Sequence Data
Nuclear Proteins--metabolism
Phosphoproteins--genetics
Promoter Regions, Genetic--genetics
Rats
Transcription Factors--genetics
Transcriptional Activation--genetics
A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2. [electronic resource] - The Journal of biological chemistry Feb 1998 - 4188-96 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.273.7.4188 doi
Animals
Apolipoprotein C-II
Apolipoproteins C--genetics
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cells, Cultured
DNA Footprinting
DNA-Binding Proteins--analysis
Gene Expression Regulation--genetics
Genes, Reporter--genetics
Hepatocyte Nuclear Factor 4
Humans
Liver--chemistry
Molecular Sequence Data
Nuclear Proteins--metabolism
Phosphoproteins--genetics
Promoter Regions, Genetic--genetics
Rats
Transcription Factors--genetics
Transcriptional Activation--genetics