mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. [electronic resource]
Producer: 19980206Description: 79-84 p. digitalISSN:- 1044-9523
- Animals
- Cell Division -- drug effects
- Cell Line
- Cysteine Endopeptidases -- metabolism
- Cysteine Proteinase Inhibitors -- pharmacology
- Humans
- Hydrolysis
- Leupeptins -- pharmacology
- Multienzyme Complexes -- metabolism
- Nuclear Proteins
- Proteasome Endopeptidase Complex
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogene Proteins c-mdm2
- Tumor Suppressor Protein p53 -- metabolism
- Ubiquitins -- metabolism
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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