mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

Chang, Y C

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. [electronic resource] - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Jan 1998 - 79-84 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1044-9523


Animals
Cell Division--drug effects
Cell Line
Cysteine Endopeptidases--metabolism
Cysteine Proteinase Inhibitors--pharmacology
Humans
Hydrolysis
Leupeptins--pharmacology
Multienzyme Complexes--metabolism
Nuclear Proteins
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53--metabolism
Ubiquitins--metabolism
bcl-2-Associated X Protein