Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen. [electronic resource]
Producer: 19980127Description: 1407-15 p. digitalISSN:- 0090-9556
- Adolescent
- Adult
- Aryl Hydrocarbon Hydroxylases
- Child
- Coumarins -- metabolism
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP2E1 Inhibitors
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- genetics
- Cytochromes b5 -- metabolism
- Enzyme Activation -- drug effects
- Female
- Humans
- Kinetics
- Male
- Methoxsalen -- pharmacology
- Microsomes, Liver -- drug effects
- Middle Aged
- Mixed Function Oxygenases -- antagonists & inhibitors
- NADP -- metabolism
- NADPH-Ferrihemoprotein Reductase -- metabolism
- Recombinant Proteins -- isolation & purification
- Spectrophotometry
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- antagonists & inhibitors
- Time Factors
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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