Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen.

Koenigs, L L

Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Dec 1997 - 1407-15 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0090-9556


Adolescent
Adult
Aryl Hydrocarbon Hydroxylases
Child
Coumarins--metabolism
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2A6
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP2E1 Inhibitors
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--genetics
Cytochromes b5--metabolism
Enzyme Activation--drug effects
Female
Humans
Kinetics
Male
Methoxsalen--pharmacology
Microsomes, Liver--drug effects
Middle Aged
Mixed Function Oxygenases--antagonists & inhibitors
NADP--metabolism
NADPH-Ferrihemoprotein Reductase--metabolism
Recombinant Proteins--isolation & purification
Spectrophotometry
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases--antagonists & inhibitors
Time Factors