Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. [electronic resource]
Producer: 19970417Description: 695-704 p. digitalISSN:- 0022-2623
- Animals
- Benzamides -- chemical synthesis
- Binding, Competitive
- Brain -- metabolism
- Crystallography, X-Ray
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Enkephalin, Leucine-2-Alanine -- metabolism
- Enkephalins -- metabolism
- Guinea Pigs
- Ileum -- metabolism
- Magnetic Resonance Spectroscopy
- Male
- Mice
- Molecular Conformation
- Molecular Structure
- Muscle Contraction -- drug effects
- Piperazines -- chemical synthesis
- Radioligand Assay
- Rats
- Receptors, Opioid, delta -- agonists
- Receptors, Opioid, mu -- metabolism
- Stereoisomerism
- Vas Deferens -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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