Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.

Calderon, S N

Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. [electronic resource] - Journal of medicinal chemistry Feb 1997 - 695-704 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm960319n doi


Animals
Benzamides--chemical synthesis
Binding, Competitive
Brain--metabolism
Crystallography, X-Ray
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
Enkephalin, Leucine-2-Alanine--metabolism
Enkephalins--metabolism
Guinea Pigs
Ileum--metabolism
Magnetic Resonance Spectroscopy
Male
Mice
Molecular Conformation
Molecular Structure
Muscle Contraction--drug effects
Piperazines--chemical synthesis
Radioligand Assay
Rats
Receptors, Opioid, delta--agonists
Receptors, Opioid, mu--metabolism
Stereoisomerism
Vas Deferens--metabolism