Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. [electronic resource]
Producer: 19970417Description: 677-83 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Division -- drug effects
- Crystallography, X-Ray
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Escherichia coli -- enzymology
- Humans
- Magnetic Resonance Spectroscopy
- Mice
- Models, Molecular
- Molecular Conformation
- Molecular Structure
- Neoplasms, Experimental -- drug therapy
- Quinazolines -- chemical synthesis
- Structure-Activity Relationship
- Sulfones -- chemical synthesis
- Sulfoxides -- chemical synthesis
- Thymidylate Synthase -- antagonists & inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article
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