The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. [electronic resource]
Producer: 19970415Description: 5682-8 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Animals
- Antifungal Agents -- pharmacology
- Candida albicans -- enzymology
- Cytochrome P-450 Enzyme System -- genetics
- Drug Resistance, Microbial
- Electron Spin Resonance Spectroscopy
- Fluconazole -- pharmacology
- Humans
- Kinetics
- Molecular Sequence Data
- Mutagenesis
- Oxidoreductases -- genetics
- Rats
- Restriction Mapping
- Sequence Alignment
- Sterol 14-Demethylase
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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