The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity.

Lamb, D C

The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. [electronic resource] - The Journal of biological chemistry Feb 1997 - 5682-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.272.9.5682 doi


Amino Acid Sequence
Animals
Antifungal Agents--pharmacology
Candida albicans--enzymology
Cytochrome P-450 Enzyme System--genetics
Drug Resistance, Microbial
Electron Spin Resonance Spectroscopy
Fluconazole--pharmacology
Humans
Kinetics
Molecular Sequence Data
Mutagenesis
Oxidoreductases--genetics
Rats
Restriction Mapping
Sequence Alignment
Sterol 14-Demethylase