Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activated protein kinase by bpV(phen). [electronic resource]
Producer: 19970218Description: 138-45 p. digitalISSN:- 0021-9258
- Androstadienes -- pharmacology
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases -- metabolism
- Cells, Cultured
- Dexamethasone -- pharmacology
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Glucagon -- pharmacology
- Insulin -- pharmacology
- Insulin-Like Growth Factor Binding Protein 1 -- genetics
- Insulin-Like Growth Factor Binding Protein 4 -- genetics
- Liver -- metabolism
- MAP Kinase Kinase 1
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Organometallic Compounds -- pharmacology
- Phenanthrolines -- pharmacology
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor) -- physiology
- Polyenes -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein Tyrosine Phosphatases -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- RNA, Messenger -- genetics
- Rats
- Rats, Sprague-Dawley
- Ribosomal Protein S6 Kinases
- Signal Transduction
- Sirolimus
- Wortmannin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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