Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activated protein kinase by bpV(phen).

Band, C J

Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activated protein kinase by bpV(phen). [electronic resource] - The Journal of biological chemistry Jan 1997 - 138-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.272.1.138 doi


Androstadienes--pharmacology
Animals
Calcium-Calmodulin-Dependent Protein Kinases--metabolism
Cells, Cultured
Dexamethasone--pharmacology
Enzyme Activation
Enzyme Inhibitors--pharmacology
Glucagon--pharmacology
Insulin--pharmacology
Insulin-Like Growth Factor Binding Protein 1--genetics
Insulin-Like Growth Factor Binding Protein 4--genetics
Liver--metabolism
MAP Kinase Kinase 1
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Organometallic Compounds--pharmacology
Phenanthrolines--pharmacology
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)--physiology
Polyenes--pharmacology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein Tyrosine Phosphatases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
RNA, Messenger--genetics
Rats
Rats, Sprague-Dawley
Ribosomal Protein S6 Kinases
Signal Transduction
Sirolimus
Wortmannin