Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. [electronic resource]
Producer: 19961217Description: 3926-36 p. digitalISSN:- 0006-4971
- Cell Differentiation -- drug effects
- Cell Division -- drug effects
- Chromosomes, Human, Pair 15 -- genetics
- Chromosomes, Human, Pair 17 -- genetics
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Leukemic -- drug effects
- Humans
- Interferon alpha-2
- Interferon-alpha -- pharmacology
- Interferon-gamma -- pharmacology
- Leukemia, Promyelocytic, Acute -- genetics
- Leukocytes -- drug effects
- Neoplasm Proteins -- biosynthesis
- Neoplastic Stem Cells -- drug effects
- Nuclear Proteins
- Oncogene Proteins, Fusion -- biosynthesis
- Promyelocytic Leukemia Protein
- Recombinant Proteins
- Transcription Factors -- biosynthesis
- Translocation, Genetic
- Tretinoin -- pharmacology
- Tumor Cells, Cultured
- Tumor Suppressor Proteins
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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