Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.

Nason-Burchenal, K

Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. [electronic resource] - Blood Nov 1996 - 3926-36 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0006-4971


Cell Differentiation--drug effects
Cell Division--drug effects
Chromosomes, Human, Pair 15--genetics
Chromosomes, Human, Pair 17--genetics
Drug Resistance, Neoplasm--genetics
Gene Expression Regulation, Leukemic--drug effects
Humans
Interferon alpha-2
Interferon-alpha--pharmacology
Interferon-gamma--pharmacology
Leukemia, Promyelocytic, Acute--genetics
Leukocytes--drug effects
Neoplasm Proteins--biosynthesis
Neoplastic Stem Cells--drug effects
Nuclear Proteins
Oncogene Proteins, Fusion--biosynthesis
Promyelocytic Leukemia Protein
Recombinant Proteins
Transcription Factors--biosynthesis
Translocation, Genetic
Tretinoin--pharmacology
Tumor Cells, Cultured
Tumor Suppressor Proteins