Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. [electronic resource]
Producer: 19961224Description: 12240-4 p. digitalISSN:- 0027-8424
- Amyotrophic Lateral Sclerosis -- enzymology
- Binding Sites
- Cobalt -- metabolism
- Copper -- metabolism
- Electron Spin Resonance Spectroscopy
- Humans
- Hydrogen-Ion Concentration
- Mutagenesis, Site-Directed
- Oxidation-Reduction
- Polymerase Chain Reaction
- Spectrophotometry, Ultraviolet
- Superoxide Dismutase -- genetics
- Zinc -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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