Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.

Lyons, T J

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Oct 1996 - 12240-4 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0027-8424

10.1073/pnas.93.22.12240 doi


Amyotrophic Lateral Sclerosis--enzymology
Binding Sites
Cobalt--metabolism
Copper--metabolism
Electron Spin Resonance Spectroscopy
Humans
Hydrogen-Ion Concentration
Mutagenesis, Site-Directed
Oxidation-Reduction
Polymerase Chain Reaction
Spectrophotometry, Ultraviolet
Superoxide Dismutase--genetics
Zinc--metabolism