Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. [electronic resource]
Producer: 19960820Description: 15782-6 p. digitalISSN:- 0021-9258
- Arginine
- Base Sequence
- Breast Neoplasms -- genetics
- Carcinoma, Ductal, Breast -- genetics
- Cell Cycle
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Cyclins -- antagonists & inhibitors
- DNA Primers -- chemistry
- Female
- Humans
- Molecular Sequence Data
- Oncogene Proteins -- antagonists & inhibitors
- Point Mutation
- Protein Binding
- Structure-Activity Relationship
- Tryptophan
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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