Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

Balbín, M

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. [electronic resource] - The Journal of biological chemistry Jun 1996 - 15782-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.271.26.15782 doi


Arginine
Base Sequence
Breast Neoplasms--genetics
Carcinoma, Ductal, Breast--genetics
Cell Cycle
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases--antagonists & inhibitors
Cyclins--antagonists & inhibitors
DNA Primers--chemistry
Female
Humans
Molecular Sequence Data
Oncogene Proteins--antagonists & inhibitors
Point Mutation
Protein Binding
Structure-Activity Relationship
Tryptophan