Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. [electronic resource]
Producer: 19960301Description: 224-36 p. digitalISSN:- 0022-2623
- 3T3 Cells
- Alkyl and Aryl Transferases
- Animals
- Antineoplastic Agents -- chemical synthesis
- Brain -- enzymology
- Cell Division -- drug effects
- Cell Line, Transformed
- Cell Transformation, Neoplastic -- drug effects
- Drug Design
- Enzyme Inhibitors -- chemical synthesis
- Genes, ras -- genetics
- Glutamates -- chemical synthesis
- Isoquinolines -- chemical synthesis
- Methionine -- analogs & derivatives
- Mice
- Mice, Nude
- Molecular Structure
- Neoplasm Transplantation
- Oncogene Protein p21(ras) -- metabolism
- Protein Prenylation -- drug effects
- Rats
- Swine
- Tetrahydroisoquinolines
- Transfection
- Transferases -- antagonists & inhibitors
- Tumor Cells, Cultured
- Valine -- analogs & derivatives
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Publication Type: Journal Article
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