Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Leftheris, K
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. [electronic resource] - Journal of medicinal chemistry Jan 1996 - 224-36 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm950642a doi
3T3 Cells
Alkyl and Aryl Transferases
Animals
Antineoplastic Agents--chemical synthesis
Brain--enzymology
Cell Division--drug effects
Cell Line, Transformed
Cell Transformation, Neoplastic--drug effects
Drug Design
Enzyme Inhibitors--chemical synthesis
Genes, ras--genetics
Glutamates--chemical synthesis
Isoquinolines--chemical synthesis
Methionine--analogs & derivatives
Mice
Mice, Nude
Molecular Structure
Neoplasm Transplantation
Oncogene Protein p21(ras)--metabolism
Protein Prenylation--drug effects
Rats
Swine
Tetrahydroisoquinolines
Transfection
Transferases--antagonists & inhibitors
Tumor Cells, Cultured
Valine--analogs & derivatives
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. [electronic resource] - Journal of medicinal chemistry Jan 1996 - 224-36 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm950642a doi
3T3 Cells
Alkyl and Aryl Transferases
Animals
Antineoplastic Agents--chemical synthesis
Brain--enzymology
Cell Division--drug effects
Cell Line, Transformed
Cell Transformation, Neoplastic--drug effects
Drug Design
Enzyme Inhibitors--chemical synthesis
Genes, ras--genetics
Glutamates--chemical synthesis
Isoquinolines--chemical synthesis
Methionine--analogs & derivatives
Mice
Mice, Nude
Molecular Structure
Neoplasm Transplantation
Oncogene Protein p21(ras)--metabolism
Protein Prenylation--drug effects
Rats
Swine
Tetrahydroisoquinolines
Transfection
Transferases--antagonists & inhibitors
Tumor Cells, Cultured
Valine--analogs & derivatives