Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin. [electronic resource]
Producer: 19930707Description: 5374-7 p. digitalISSN:- 0027-8424
- Amino Acid Sequence
- Animals
- Baculoviridae -- genetics
- Base Sequence
- Cell Line
- Chromatography, Affinity
- Fibrinolysin -- chemistry
- Histidine
- Humans
- Imidazoles -- pharmacology
- Isoflurophate -- pharmacology
- Kinetics
- Molecular Sequence Data
- Moths
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Proline
- Protein Conformation
- Recombinant Proteins -- chemistry
- Transfection
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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