Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin.

Mhashilkar, A M

Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Jun 1993 - 5374-7 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0027-8424

10.1073/pnas.90.11.5374 doi


Amino Acid Sequence
Animals
Baculoviridae--genetics
Base Sequence
Cell Line
Chromatography, Affinity
Fibrinolysin--chemistry
Histidine
Humans
Imidazoles--pharmacology
Isoflurophate--pharmacology
Kinetics
Molecular Sequence Data
Moths
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Proline
Protein Conformation
Recombinant Proteins--chemistry
Transfection