The mutagenicity and interactions of 2- and 4-(acetylamino)fluorene with cytochrome P450 and the aromatic hydrocarbon receptor may explain the difference in their carcinogenic potency. [electronic resource]
Producer: 19931018Description: 535-41 p. digitalISSN:- 0893-228X
- 2-Acetylaminofluorene -- analogs & derivatives
- Animals
- Aroclors -- pharmacology
- Binding, Competitive -- drug effects
- Carcinogens -- chemistry
- Chlorodiphenyl (54% Chlorine)
- Cytochrome P-450 Enzyme System -- biosynthesis
- Cytosol -- drug effects
- Enzyme Induction -- drug effects
- Immunoblotting
- In Vitro Techniques
- Isomerism
- Male
- Microsomes, Liver -- drug effects
- Mutagenicity Tests
- Mutagens -- toxicity
- Polychlorinated Dibenzodioxins -- metabolism
- Rats
- Rats, Wistar
- Receptors, Aryl Hydrocarbon
- Receptors, Drug -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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