The mutagenicity and interactions of 2- and 4-(acetylamino)fluorene with cytochrome P450 and the aromatic hydrocarbon receptor may explain the difference in their carcinogenic potency.

Ioannides, C

The mutagenicity and interactions of 2- and 4-(acetylamino)fluorene with cytochrome P450 and the aromatic hydrocarbon receptor may explain the difference in their carcinogenic potency. [electronic resource] - Chemical research in toxicology - 535-41 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0893-228X

10.1021/tx00034a023 doi


2-Acetylaminofluorene--analogs & derivatives
Animals
Aroclors--pharmacology
Binding, Competitive--drug effects
Carcinogens--chemistry
Chlorodiphenyl (54% Chlorine)
Cytochrome P-450 Enzyme System--biosynthesis
Cytosol--drug effects
Enzyme Induction--drug effects
Immunoblotting
In Vitro Techniques
Isomerism
Male
Microsomes, Liver--drug effects
Mutagenicity Tests
Mutagens--toxicity
Polychlorinated Dibenzodioxins--metabolism
Rats
Rats, Wistar
Receptors, Aryl Hydrocarbon
Receptors, Drug--drug effects